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IL-2信息

英文名称:Interleukin-2
中文名称:白细胞介素-2
靶点别称:T-cell growth factor,IL2,Interleukin 2,T Cell Growth Factor,Aldesleukin,IL-2,TCGF,Involved In Regulation Of T-Cell Clonal Expansion,Interleukin-2,Lymphokine
上市药物数量:2
临床药物数量:10
最高研发阶段:批准上市

IL-2产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
IL2-H4113
Human
Human IL-2 Protein, Tag Free
IL2-H82F3
Human
Biotinylated Human IL-2 Protein, Fc,Avitag
IL2-H82E4
Human
Biotinylated Human IL-2 Protein, His,Avitag™
IL2-H52H8
Human
Human IL-2 Protein, His Tag
IL2-M52H3
Mouse
Mouse IL-2 Protein, His Tag
IL2-H5269
Human
Human IL-2 Protein, Fc Tag (MALS verified)
 
评论(2)
IL2-H82E4|Biotinylated Human IL-2 Protein, His,Avitag™
  1. 176XXXXXXX5
  2. 2人赞
  3. 非常好用的产品,及时有效的对我的实验反馈,希望以后可以一直合作!!也希望厂家多多拓展业务到更多的领悟!
  4. 2021-08-17
IL2-H4113|Human IL-2 Protein, Tag Free
  1. 136XXXXXXX6
  2. 7人赞
  3. 用Ficoll提取的PBMCs,然后用K562以及IL-2来刺激NK细胞的扩增,效果很不错,NK 细胞的纯度和扩增倍数都很满意。
  4. 2019-11-13
 

IL-2 分子别名

IL2,TCGF,lymphokine,Interleukin 2

IL-2 分子背景

Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit crossspecies activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (T-regs). After exiting from the thymus, T-Regs function to prevent other T cells from recognizing and reacting against "self antigens", which could result in "autoimmunity". T-Regs do so by preventing the responding cells from producing IL-2. Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system.

IL-2 前沿进展

IL-2上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Recombinant Human Interleukin-2 Injection (Beijing Four Rings Biopharmaceutical) 重组人白介素-2注射液 (北京四环生物制药有限公司) 批准上市 北京四环生物制药有限公司 新德路生 Mainland China 血小板减少 Beijing Four Rings Bio-Pharmaceutical Co Ltd 1997-01-01 血小板减少 详情
Thalidomide 沙利度胺 NSC-66847; NSC-527179; K-17; VP-02 批准上市 Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Japan 麻风结节性红斑 Fujimoto Pharmaceutical 1982-01-01 HIV感染, 强直性脊柱炎, 骨髓增生异常综合征, 特发性肺纤维化, 多发性骨髓瘤, HIV消耗综合征, 结节性红斑, 麻风结节性红斑, 肝细胞癌 详情

IL-2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Human interleukin-2 biosimilar (Amoytop Biotech/BioGeneric Pharma) rHuIL-2 临床阶段不明 厦门特宝生物工程股份有限公司, Biogeneric 肾细胞癌, 黑色素瘤 详情
HBAI-20 HBAI-20; HBAI-20-CyTuVax 临床二期 Cytuvax 乙型肝炎 详情
Bifikafusp alfa L19-IL-2 临床三期 Philogen 头颈癌, 实体瘤, 肾细胞癌, 动脉粥样硬化, 基底细胞癌, 胰腺癌, 弥漫性大B-细胞淋巴瘤, 黑色素瘤 详情
Autologous tumor cell vaccine (NCI) 临床二期 H Lee Moffitt Cancer Center & Research Institute, 美国国立癌症研究所, Chiron Spa 肾细胞癌, 黑色素瘤 详情
ITI-1000 ITI-1000 临床二期 Immunomic Therapeutics 胶质母细胞瘤 详情
T20K T-20K 临床一期 Cyxone 多发性硬化 详情
Interleukin-2 gene therapy (St Jude Children's Research Hospital) 临床一期 圣犹达儿童研究医院, 美国国立癌症研究所 神经母细胞瘤 详情
Darleukin/fibromun L19-IL-2/ L19-TNF-α 临床三期 Philogen 黑色素瘤 详情
S-95007 S-95007 临床二期 施维雅 免疫紊乱, 炎性疾病 详情
Interleukin-2 inhalation (Immunservice) 临床三期 Immunservice 肾细胞癌 详情
TG-4010 VV-MUC-IL2; TG-4010 临床二期 Transgene 前列腺癌, 非小细胞肺癌 详情
BNT-153 BNT-153 临床一期 Biontech Se 实体瘤 详情
mRNA-6231 mRNA-6231 临床一期 Moderna Therapeutics 自身免疫疾病 详情
SHR-1916 SHR-1916 临床一期 江苏恒瑞医药股份有限公司 实体瘤 详情

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