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Human IL-2 R gamma / CD132 Protein, His Tag (MALS verified)

分子别名(Synonym)

IL2RG,CD132,CIDX,IMD4,P64,SCIDX,SCIDX1,gammaC

表达区间及表达系统(Source)

Human IL-2 R gamma, His Tag (ILA-H52H5) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Asn 254 (Accession # P31785-1).

Predicted N-terminus: Leu 23

Request for sequence

蛋白结构(Molecular Characterization)

Online(Leu 23 - Asn 254) P31785-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 29.3 kDa. The protein migrates as 55-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 . Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human IL-2 R gamma, His Tag (Cat. No. ILA-H52H5) SDS-PAGE gel

Human IL-2 R gamma, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS

Human IL-2 R gamma, His Tag (Cat. No. ILA-H52H5) MALS images

The purity of Human IL-2 R gamma, His Tag (Cat. No. ILA-H52H5) was more than 85% and the molecular weight of this protein is around 50-60 kDa verified by SEC-MALS.

Report

背景(Background)

IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).

 

前沿进展

 
 
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IL-2 R gamma靶点信息
英文全称:Interleukin-2 receptor subunit gamma
中文全称:白介素-2受体γ亚基
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:1详情
最高研发阶段:临床二期
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